A 25-year trace of methicillin-resistant Staphylococcus aureus dissemination in a geriatric hospital in Japan

We analyzed 218 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from the septicemia patients in a geriatric hospital for 25 years. These strains were classified into 11 major DNA types, A through K, and 27 minor types. The strains belonging to group A and B isolated before 199...

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Published inInternational journal of general medicine Vol. 3; pp. 399 - 405
Main Authors Sakai, Fuminori, Hanaki, Hideaki, Barada, Kazunari, Hirao, Yuriko, Inamatsu, Takashi, Nakae, Taiji, Sunakawa, Keisuke
Format Journal Article
LanguageEnglish
Published New Zealand Taylor & Francis Ltd 09.12.2010
Dove Press
Dove Medical Press
Subjects
antibiotic resistance
DNA typing
geriatric hospital
Geriatrics
methicillin-resistant Staphylococcus aureus
Original Research
Staphylococcus infections
survey
geriatric hospital
methicillin-resistant Staphylococcus aureus
survey
antibiotic resistance
DNA typing
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Summary:We analyzed 218 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from the septicemia patients in a geriatric hospital for 25 years. These strains were classified into 11 major DNA types, A through K, and 27 minor types. The strains belonging to group A and B isolated before 1990 were susceptible to imipenem (IPM), fluoroquinolone, and most other antibiotics tested, except that they were markedly resistant to gentamicin. Strains mostly isolated in 1985 and thereafter were classified into group C through K, and they were mainly resistant to IPM, fluoroquinolones, and clindamycin. Analysis of the MRSA marker gene, staphylococcal cassette chromosome mec (SCCmec), of these strains revealed that the strains in groups A and B had mainly type IV and type I, respectively, and that strains in groups C through J had mainly type II. These results suggested that the strains holding type II SCCmec were resistant to IPM, fluoroquinolone, and clindamycin and they were dominant-resistant type after late 1980s. The antibiotic resistance profiles of MRSA dramatically changed during late 1980s, and these were correlated with the SCCmec types. The lesson from this study would be that consistent execution of surveillance study is needed to update the resistant profiles.
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ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S14729