Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, t...

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Published inBeilstein journal of organic chemistry Vol. 17; no. 1; pp. 2462 - 2476
Main Authors Liu, Yi, Luo, Puying, Fu, Yang, Hao, Tianxin, Liu, Xuan, Ding, Qiuping, Peng, Yiyuan
Format Journal Article
LanguageEnglish
Published Frankfurt am Main Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 22.09.2021
Beilstein-Institut
Subjects
1,3-enyne
Acids
Alkylation
Ammonia
Bromination
Chemistry
Esterification
Free radicals
functionalization
Hydroxylation
Iodination
Laboratories
pyridine
Pyridines
pyrrole
Reaction mechanisms
Review
tandem annulation
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Summary:Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenylation, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.
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ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.17.163