Draft genome sequence of a GES-5-producing Serratia marcescens isolated in southern Brazil

• Published in: Brazilian journal of microbiology Vol. 48; no. 2; pp. 191 - 192
• Main Authors: Nodari, Carolina Silva, Siebert, Marina, Matte, Ursula da Silveira, Barth, Afonso Luís
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Elsevier Editora Ltda 01.04.2017; Springer Nature B.V; Elsevier; Sociedade Brasileira de Microbiologia
• Subjects: Bacteria; beta-Lactamases - genetics; beta-Lactamases - secretion; Brazil; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; Efflux; Enzymes; Genome Announcements; Genome, Bacterial; Genomes; GES-5; Humans; Membrane Transport Proteins - genetics; MICROBIOLOGY; Nucleotide sequence; Polymyxins; Sequence Analysis, DNA; Serratia marcescens; Serratia marcescens - enzymology; Serratia marcescens - genetics; Serratia marcescens - isolation & purification; Tetracyclines; Transferases - metabolism; Urinary tract; Whole-genome sequencing; Wounds; Brazil; GES-5; Whole-genome sequencing; Serratia marcescens
• ISSN: 1517-8382; 1678-4405; 1678-4405
• DOI: 10.1016/j.bjm.2016.08.002

Serratia marcescens is a Gram-negative rod intrinsically resistant to polymyxins and usually associated with wound, respiratory and urinary tract infections. The whole genome of the first GES-5-producing S. marcescens isolated from a Brazilian patient was sequenced using Ion Torrent PGM System. Besides blaGES-5, we were able to identify genes encoding for other β-lactamases, for aminoglycoside modifying enzymes and for an efflux pump to tetracyclines.