Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

• Published in: Neurocritical care Vol. 35; no. Suppl 1; pp. 4 - 23
• Main Authors: Claassen, Jan, Akbari, Yama, Alexander, Sheila, Bader, Mary Kay, Bell, Kathleen, Bleck, Thomas P., Boly, Melanie, Brown, Jeremy, Chou, Sherry H.-Y., Diringer, Michael N., Edlow, Brian L., Foreman, Brandon, Giacino, Joseph T., Gosseries, Olivia, Green, Theresa, Greer, David M., Hanley, Daniel F., Hartings, Jed A., Helbok, Raimund, Hemphill, J. Claude, Hinson, H. E., Hirsch, Karen, Human, Theresa, James, Michael L., Ko, Nerissa, Kondziella, Daniel, Livesay, Sarah, Madden, Lori K., Mainali, Shraddha, Mayer, Stephan A., McCredie, Victoria, McNett, Molly M., Meyfroidt, Geert, Monti, Martin M., Muehlschlegel, Susanne, Murthy, Santosh, Nyquist, Paul, Olson, DaiWai M., Provencio, J. Javier, Rosenthal, Eric, Sampaio Silva, Gisele, Sarasso, Simone, Schiff, Nicholas D., Sharshar, Tarek, Shutter, Lori, Stevens, Robert D., Vespa, Paul, Videtta, Walter, Wagner, Amy, Ziai, Wendy, Whyte, John, Zink, Elizabeth, Suarez, Jose I.
• Format: Journal Article Web Resource
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V; Humana Press
• Subjects: Biomarkers; Brain research; Classification; Clinical trials; Cognition & reasoning; Coma; Coma - diagnosis; Coma - therapy; Congresses as Topic; Consciousness; Consciousness Disorders - diagnosis; Consciousness Disorders - therapy; Coronaviruses; COVID-19; Critical Care Medicine; Curing Coma Campaign; Electrophysiology; Genotype & phenotype; Human health sciences; Humans; Intensive; Internal Medicine; Magnetic resonance imaging; Medicine; Medicine & Public Health; National Institutes of Health (U.S.); Neurologie; Neurology; Neurosurgery; Patients; Sciences de la santé humaine; The Curing Coma Campaign; Traumatic brain injury; Unconsciousness; United States; United States; Coma; Electrophysiology; Biomarkers; Consciousness; Magnetic resonance imaging
• ISSN: 1541-6933; 1556-0961; 1556-0961
• DOI: 10.1007/s12028-021-01260-x

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.