The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains

• Published in: Journal of neuroimmunology Vol. 204; no. 1; pp. 43 - 51
• Main Authors: Yasuda, Y, Shimoda, T, Uno, K, Tateishi, N, Furuya, S, Yagi, K, Suzuki, K, Fujita, S
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2008
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology; Allergy and Immunology; Analysis of Variance; Animals; Astrocytes - drug effects; Chemokine; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cytokine; Cytokines - blood; Cytokines - cerebrospinal fluid; Drug Administration Schedule; Glia; Male; Mice; Mice, Inbred Strains; Microglia - drug effects; Movement - drug effects; MPTP sensitivity; Nerve Growth Factors - metabolism; Neurology; Neurotoxins - pharmacology; S100 Calcium Binding Protein beta Subunit; S100 Proteins - metabolism; Species Specificity; Strain difference; Time Factors; Tyrosine 3-Monooxygenase - metabolism; Strain difference; Chemokine; Mice; Glia; Cytokine; MPTP sensitivity
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2008.08.003

Abstract The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-γ, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.