High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy

• Published in: European journal of medical research Vol. 30; no. 1; pp. 50 - 7
• Main Authors: Zhang, Meng, Gao, Wei, Cui, Xiaotong, Han, Xueting, Xu, Yamei, Zhou, Jingmin, Ge, Junbo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.01.2025; BioMed Central; BMC
• Subjects: Aged; Apical Hypertrophic Cardiomyopathy; Atrial fibrillation; Biomarkers - blood; Cardiomyopathy, Hypertrophic; Cardiomyopathy, Hypertrophic - blood; Cardiomyopathy, Hypertrophic - diagnostic imaging; Cardiomyopathy, Hypertrophic - pathology; Echocardiography; Female; Heart Ventricles - diagnostic imaging; Heart Ventricles - pathology; High-sensitive cardiac troponin T; Humans; Left ventricular apical thickness; Male; Middle Aged; N-terminal pro-BNP; Natriuretic Peptide, Brain - blood; Peptide Fragments - blood; Retrospective Studies; Risk factors; Troponin T - blood; Left ventricular apical thickness; High-sensitive cardiac troponin T; Apical hypertrophic cardiomyopathy; N-terminal pro-BNP
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-024-02222-7

Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear. We retrospectively screened AHCM patients between January 2019 and December 2021 in Zhongshan Hospital Fudan University. The relationship between the level of hs-cTNT, NT-proBNP and echocardiography parameters were analyzed. The risk factors for elevated hs-cTNT and NT-proBNP level were investigated with linear regression analysis. A total of 267 AHCM patients were enrolled. They were divided into hs-cTNT normal (129, 48.3%) and abnormal (138, 51.7%) group. Compared with hs-cTNT normal group, hs-cTNT abnormal group were elder (68.3 ± 11.6 vs. 63.8 ± 10.6, P = 0.001); with higher rate of atrial fibrillation (AF) (41.3% vs. 17.8%, P < 0.001) and higher level of NT-proBNP concentration (752.0 [343.8-1345.5] vs. 249.0 [104.0-541.0], P < 0.001). For echocardiography parameters, hs-cTNT abnormal patients have thicker interventricular septum (IVS) (11.6 ± 2.0 vs. 11.0 ± 1.7, P = 0.02), thicker left ventricular apical (LVA) (16.9 ± 3.0 vs. 14.9 ± 2.3, P < 0.001) and larger left atrium diameter (LAD) (45.9 ± 6.6 vs. 42.4 ± 5.1, P < 0.001). LVA was independently correlated with both the level of hs-cTNT and NT-proBNP (hs-cTNT r = 0.224, P = 0.143; NT-proBNP r = 0.370, P < 0.001). Linear regression analysis revealed that LVA was independent risk factor of both the elevated hs-cTNT and NT-proBNP level. More than half of AHCM patients had abnormal hs-cTNT level. LVA was positively and independently correlated with the level of hs-cTNT and NT-proBNP.