Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions wi...

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Bibliographic Details
Published inNature biotechnology Vol. 22; no. 7; pp. 863 - 866
Main Authors Langer, Robert, Anderson, Daniel G, Levenberg, Shulamit
Format Journal Article
LanguageEnglish
Published New York, NY Nature 01.07.2004
Nature Publishing Group
Subjects
Biocompatible Materials - chemical synthesis
Biocompatible Materials - pharmacology
Biological and medical sciences
Biotechnology
Combinatorial Chemistry Techniques - methods
Embryo, Mammalian - cytology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Microarray Analysis - methods
Miscellaneous
Polymers - chemical synthesis
Polymers - pharmacology
Stem Cells - drug effects
Stem Cells - metabolism
Human
Cell proliferation
Array
Embryo
Support
Tissue engineering
Stem cell
Interaction
Polymer
Biomaterial
Application
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Summary:Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
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ISSN:1087-0156
1546-1696
DOI:10.1038/nbt981