Severe asthmatic airways have distinct circadian clock gene expression pattern associated with WNT signaling

[...]the lack of information on specific sampling times restricted our analysis although bronchial epithelial brushing samples are likely collected during regular operation hours and we have considered diurnal variations in our analysis (Figure 1C). [...]we cannot exclude potential influence of asth...

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Published inClinical and translational allergy Vol. 14; no. 7; pp. e12379 - n/a
Main Authors Tran, Nguyen Quoc Vuong, Le, Minh Khang, Nakamura, Yuki, Nakao, Atsuhito
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.07.2024
John Wiley and Sons Inc
Wiley
Subjects
Asthma
Chronic obstructive pulmonary disease
Circadian rhythm
Conflicts of interest
Datasets
Gene expression
Letter
Regression analysis
Writing
Online AccessGet full text
ISSN2045-7022
2045-7022
DOI10.1002/clt2.12379

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Summary:[...]the lack of information on specific sampling times restricted our analysis although bronchial epithelial brushing samples are likely collected during regular operation hours and we have considered diurnal variations in our analysis (Figure 1C). [...]we cannot exclude potential influence of asthma treatment including corticosteroid, 10 since most patients in the datasets, except for GSE67472, were on asthma medication. In summary, we show that severe asthmatic airways have distinct circadian clock gene expression patterns associated with WNT signaling, a crucial pathway for airway remodeling in asthma. [...]disturbance of airway circadian clock activity may be one of the determining features of severe asthma.
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ISSN:2045-7022
2045-7022
DOI:10.1002/clt2.12379