Recurrent inhibition of wrist extensor motoneurones: a single unit study on a deafferented patient

• Published in: The Journal of physiology Vol. 549; no. 3; pp. 975 - 984
• Main Authors: Mattei, Benjamin, Schmied, Annie, Vedel, Jean‐Pierre
• Format: Journal Article
• Language: English
• Published: Oxford, UK The Physiological Society 15.06.2003; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Action Potentials - physiology; Adult; Denervation; Electric Stimulation; Electromyography; Excitatory Postsynaptic Potentials - physiology; Female; Humans; Microelectrodes; Middle Aged; Motor Neurons - physiology; Muscle, Skeletal - innervation; Muscle, Skeletal - physiology; Neurons, Afferent - physiology; Original; Radial Nerve - physiology; Wrist - innervation; Wrist - physiology
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/jphysiol.2003.039040

In order to document the effects of recurrent inhibition on the firing times of human α-motoneurones during natural motor behaviour, a case study was performed on a deafferented patient. The fact that this subject had completely lost the large-diameter sensory afferents provided us with a unique opportunity of selectively stimulating the motor axons in the nerves. The tonic activity of single motor units ( n = 21) was recorded in the extensor carpi radialis muscles while applying randomly timed antidromic electrical stimuli to the radial nerve. The peristimulus time histogram analysis showed the presence of biphasic inhibitory effects, including an early, short-lasting component followed by a longer-lasting component occurring 20–40 ms later. The interspike interval (ISI) during which the stimulation occurred was generally lengthened as compared to the previous ISIs. The stimulation was most effective when delivered early (20–30 ms) after a spike. It was also effective, although less so, when delivered at the end of the ISI (70–100 ms after a spike). The lengthening effect sometimes extended over one or two of the subsequent ISIs. The lengthening effect of the motor axon stimulation was followed by an excitatory-like effect, which took the form of a shortening that affected up to five ISIs after the stimulation. The biphasic inhibitory effects and the subsequent facilitatory effects are discussed in terms of the dual nature of the synaptic processes involved in the recurrent inhibitory network, the postactivation facilitation/depression processes and the mutual inhibition occurring between Renshaw cells.