From meiosis to postmeiotic events: The secrets of histone disappearance

One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come t...

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Bibliographic Details
Published inThe FEBS journal Vol. 277; no. 3; pp. 599 - 604
Main Authors Gaucher, Jonathan, Reynoird, Nicolas, Montellier, Emilie, Boussouar, Fayçal, Rousseaux, Sophie, Khochbin, Saadi
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.02.2010
Blackwell Publishing Ltd
Subjects
Acetylation
Animals
Cell division
Cellular biology
chromatin
Chromatin - metabolism
Chromosomal Proteins, Non-Histone - physiology
epigenetics
Genomics
Histone Deacetylases - genetics
histone variants
Histones - metabolism
Humans
Male
Meiosis - physiology
Mice
nucleosomes
Nucleosomes - drug effects
Nucleosomes - metabolism
protamines
Protamines - metabolism
protease
Proteases
Proteins
sperm
Spermatids - metabolism
Spermatogenesis - genetics
spermatozoa
transition proteins
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Summary:One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
Bibliography:http://dx.doi.org/10.1111/j.1742-4658.2009.07504.x
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ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2009.07504.x