Genomic organization of microRNAs
microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of develo...
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Published in | Journal of cellular physiology Vol. 222; no. 3; pp. 540 - 545 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.03.2010
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Subjects | |
Online Access | Get full text |
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Summary: | microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of development, maintenance, and disease, and are largely evolutionarily conserved in metazoans. Searching the genomes of organisms from viruses to worms to humans has revealed potentially thousands of miRNA genes. Understanding the patterns of genomic organization between species cannot only help to refine tools to identify new miRNAs, but also provide insight into miRNA biogenesis and function. J. Cell. Physiol. 222: 540–545, 2010. © 2009 Wiley‐Liss, Inc. |
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Bibliography: | ArticleID:JCP21993 ark:/67375/WNG-WLLHTJXT-V istex:005CCC3129943DE58B06D5244541447CA1D360B4 NIH - No. GM 075790 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0021-9541 1097-4652 |
DOI: | 10.1002/jcp.21993 |