Genomic organization of microRNAs

microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of develo...

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Bibliographic Details
Published inJournal of cellular physiology Vol. 222; no. 3; pp. 540 - 545
Main Authors Olena, Abigail F., Patton, James G.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2010
Subjects
3' Untranslated Regions
Animals
Evolution, Molecular
Gene Expression Regulation
Genome
Genomics
Humans
MicroRNAs - biosynthesis
MicroRNAs - metabolism
Protein Biosynthesis
RNA Stability
RNA, Messenger - metabolism
Species Specificity
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Summary:microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of development, maintenance, and disease, and are largely evolutionarily conserved in metazoans. Searching the genomes of organisms from viruses to worms to humans has revealed potentially thousands of miRNA genes. Understanding the patterns of genomic organization between species cannot only help to refine tools to identify new miRNAs, but also provide insight into miRNA biogenesis and function. J. Cell. Physiol. 222: 540–545, 2010. © 2009 Wiley‐Liss, Inc.
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ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.21993