Studies on Positive Inotropic Agents. II. : Synthesis of(4-Substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone Derivatives

Many (1-piperazinylcarbonyl)-2(1H)-quinolinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. Among them, 3, 4-dihydro-6-[4-(3-oxo-3-phenylpropyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIj) and 3, 4-dihydro-6-[4-(oxo-4-phenylbutyl)-1-piperazinylca...

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Published inChemical & pharmaceutical bulletin Vol. 34; no. 2; pp. 682 - 693
Main Authors TOMINAGA, MICHIAKI, YO, EIYU, OGAWA, HIDENORI, YAMASHITA, SHUJI, YABUUCHI, YOUICHI, NAKAGAWA, KAZUYUKI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1986
Maruzen
Subjects
Animals
biological activity
Cardiotonic Agents - chemical synthesis
Chemical Phenomena
Chemistry
Dogs
Exact sciences and technology
Heart Rate - drug effects
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
In Vitro Techniques
Myocardial Contraction - drug effects
Organic chemistry
Piperazines - chemical synthesis
Piperazines - pharmacology
Preparations and properties
Quinolines - chemical synthesis
Quinolines - pharmacology
Cardiotonic agent
Nitrogen heterocycle
Six membered ring
Lactam
Bicyclic compound
Carboxamide
Aromatic compound
Biological activity
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Summary:Many (1-piperazinylcarbonyl)-2(1H)-quinolinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. Among them, 3, 4-dihydro-6-[4-(3-oxo-3-phenylpropyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIj) and 3, 4-dihydro-6-[4-(oxo-4-phenylbutyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIl) were found to have potent activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.34.682