Decomposition of Thymidine by Low-Energy Electrons: Implications for the Molecular Mechanisms of Single-Strand Breaks in DNA

The damage to biological systems by high‐energy quanta occurs mainly through secondary species created in the ionization path. Interaction of the low‐energy (0–3 eV) electrons with thymidine (Td) in the gas phase was investigated. These electrons induce loss of hydrogen from the N3 position and scis...

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Published inAngewandte Chemie International Edition Vol. 45; no. 12; pp. 1893 - 1896
Main Authors Ptasińska, Sylwia, Denifl, Stephan, Gohlke, Sascha, Scheier, Paul, Illenberger, Eugen, Märk, Tilmann D.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 13.03.2006
WILEY‐VCH Verlag
Subjects
anions
DNA Breaks, Single-Stranded
DNA damage
electron attachment
Electrons
gas-phase reactions
Linear Energy Transfer
nucleotides
Thermodynamics
Thymidine - chemistry
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Summary:The damage to biological systems by high‐energy quanta occurs mainly through secondary species created in the ionization path. Interaction of the low‐energy (0–3 eV) electrons with thymidine (Td) in the gas phase was investigated. These electrons induce loss of hydrogen from the N3 position and scission of the N1C1 bond. The transfer of excess electrons, initially localized on thymine, to the sugar moiety was not observed.
Bibliography:ArticleID:ANIE200503930
Financial support from FWF (Wien), EU (Brussels) through the EPIC Network and DFG (Bonn) is gratefully acknowledged.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503930