Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia

• Published in: Scientific reports Vol. 12; no. 1; p. 14564
• Main Authors: Murakami, Yasushi, Shindo, Yuichiro, Sano, Masahiro, Okumura, Junya, Kobayashi, Hironori, Sakakibara, Toshihiro, Iguchi, Mitsutaka, Takahashi, Kunihiko, Yagi, Tetsuya, Matsui, Shigeyuki, Hasegawa, Yoshinori
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/1785; 692/699/255; Cell number; Diagnosis; Humanities and Social Sciences; Leukocytes (neutrophilic); Lymphocytes; Lymphopenia; Medical prognosis; multidisciplinary; Neutrophilia; Neutrophils; Observational studies; Pneumonia; Science; Science (multidisciplinary); Survival
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-18794-5

The prognostic significance of absolute lymphocyte count (ALC) and absolute neutrophil count (ANC) remains unclear in patients with postoperative pneumonia (POP). The study objectives were to investigate the prognostic effects of ALC and ANC in POP patients, and to evaluate the time courses of ALC and ANC during hospitalization. This post-hoc analysis of a single-center prospective observational study evaluated consecutive POP patients, and comparatively analyzed community-acquired pneumonia (CAP) patients to highlight features of POP. In total, 228 POP patients and 1027 CAP patients were assessed. Severe lymphopenia (ALC < 500 cells/μL) at diagnosis was associated with worse 90-day survival in both types of pneumonia. In POP patients, neutrophilia (ANC > 7500 cells/μL) was associated with better survival, whereas CAP patients with neutrophilia tended to have a lower survival rate. Prolonged lymphopenia and delayed increase in neutrophils were characteristic time-course changes of non-survivors in POP. The time courses of ALC and ANC between survivors and non-survivors in POP trended differently from those in CAP. Our study showed that ALC and ANC at pneumonia diagnosis can serve as prognostic factors in POP patients. Differences in time-course changes of ALC and ANC between survivors and non-survivors may provide important information for future immunological research in pneumonia.