Selenadiazole Inhibited Adenovirus-Induced Apoptosis through the Oxidative-Damage-Mediated Bcl-2/Stat 3/NF-κB Signaling Pathway

Human adenovirus type 7 (HAdV7) infection causes severe pneumonia, yet there are still no breakthroughs in treatment options for adenovirus, and the road to antiviral drug development faces major challenges. We attempted to find new drugs and we stumbled upon one: selenadiazole. Selenadiazole has be...

Full description

Saved in:
Bibliographic Details
Published inPharmaceuticals (Basel, Switzerland) Vol. 16; no. 10; p. 1474
Main Authors Liu, Xia, Lai, Jia, Su, Jingyao, Zhang, Kelan, Li, Jiali, Li, Chuqing, Ning, Zhihui, Wang, Chenyang, Zhu, Bing, Li, Yinghua, Zhao, Mingqi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
MDPI
Subjects
adenovirus
Adenovirus diseases
Adenoviruses
Antiviral agents
Apoptosis
Asymptomatic
Chemical properties
Cytokines
Cytotoxicity
Dosage and administration
Drug dosages
Drug therapy
Fibroblasts
Genomes
Health aspects
Infections
Oxidative stress
Pneumonia
Polymerase chain reaction
ROS
selenadiazole
Selenium
Testing
Viral infections
Viruses
China
Online AccessGet full text

Cover

More Information
Summary:Human adenovirus type 7 (HAdV7) infection causes severe pneumonia, yet there are still no breakthroughs in treatment options for adenovirus, and the road to antiviral drug development faces major challenges. We attempted to find new drugs and we stumbled upon one: selenadiazole. Selenadiazole has been shown to have significant anti-tumor effects due to its unique chemical structure and drug activity. However, its effectiveness against viruses has not been evaluated yet. In our study, selenadiazole also showed superior antiviral activity. In vitro experiments, selenadiazole was able to inhibit adenovirus-mediated mitochondrial-oxidative-damage-related apoptosis, and in in vivo experiments, selenadiazole was able to inhibit apoptosis by modulating the apoptotic signaling pathway Bcl-2/Stat3/NF-κB, etc., and was able to largely attenuate adenovirus-infection-induced pneumonia and lung injury in mice. This study aims to describe a new antiviral treatment option from the perspective of anti-adenovirus-mediated oxidative stress and its associated apoptosis and to provide theoretical guidance for the treatment of clinical adenovirus infection to a certain extent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16101474