Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis

A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical b...

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Published inInternal Medicine Vol. 61; no. 17; pp. 2637 - 2642
Main Authors Yamamoto, Hiroshi, Komatsu, Masamichi, Sonehara, Kei, Ikuyama, Yuichi, Urushihata, Kazuhisa, Tateishi, Kazunari, Kitaguchi, Yoshiaki, Ushuiki, Atsuhito, Asaka, Shiho, Uehara, Takeshi, Kawakami, Satoshi, Mori, Kentaro, Hamanaka, Kazutoshi, Nishie, Kenichi, Hebisawa, Akira, Hanaoka, Masayuki
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Internal Medicine 01.09.2022
Japan Science and Technology Agency
Subjects
Biopsy
Case Report
immunoglobulin (Ig) G4
immunoglobulin (Ig) G4-related disease (IgG4-RD)
Immunoglobulin G
Immunoglobulins
Internal medicine
interstitial pneumonia
Lung diseases
Patients
Pneumonia
progressive fibrosing
Submandibular gland
usual interstitial pneumonia (UIP)
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Summary:A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical biopsy was also performed. The specimens revealed usual interstitial pneumonia (UIP) pattern interstitial pneumonia with some IgG4-positive cells. The patient was subsequently followed up without treatment. His forced vital capacity and radiological findings progressively deteriorated, consistent with UIP pattern interstitial lung disease but different from a lung lesion of IgG4-RD.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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Correspondence to Dr.　Masamichi Komatsu, mskomatsu@shinshu-u.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8937-21