Subthalamic neural entropy is a feature of freezing of gait in freely moving people with Parkinson's disease

• Published in: Neurobiology of disease Vol. 108; pp. 288 - 297
• Main Authors: Syrkin-Nikolau, Judy, Koop, Mandy Miller, Prieto, Thomas, Anidi, Chioma, Afzal, Muhammad Furqan, Velisar, Anca, Blumenfeld, Zack, Martin, Talora, Trager, Megan, Bronte-Stewart, Helen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017; Elsevier
• Subjects: Alpha Rhythm; Antiparkinson Agents - therapeutic use; Beta band oscillations; Beta Rhythm; Biomechanical Phenomena; Complexity; Deep Brain Stimulation; Female; Freezing of gait; Gait Disorders, Neurologic - etiology; Gait Disorders, Neurologic - physiopathology; Gait Disorders, Neurologic - therapy; Humans; Lower Extremity - physiopathology; Male; Middle Aged; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Sample Entropy; Signal Processing, Computer-Assisted; Subthalamic nucleus; Subthalamic Nucleus - drug effects; Subthalamic Nucleus - physiopathology; Walking - physiology; Sample Entropy; Freezing of gait; Parkinson's disease; Beta band oscillations; Deep brain stimulation; Subthalamic nucleus; Complexity
• ISSN: 0969-9961; 1095-953X
• DOI: 10.1016/j.nbd.2017.09.002

The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. Methods: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc.). Tasks included standing still, instrumented forward walking, stepping in place on dual forceplates, and instrumented walking through a turning and barrier course. Results: During locomotion without FOG, Freezers showed lower beta (13–30Hz) power (P=0.036) and greater beta Sample Entropy (P=0.032), than Non-Freezers, as well as greater gait asymmetry and arrhythmicity (P<0.05 for both). No differences in alpha/beta power and/or entropy were evident at rest. During periods of FOG, Freezers showed greater alpha (8–12Hz) Sample Entropy (P<0.001) than during walking without FOG. Conclusions: A novel turning and barrier course was superior to FW in eliciting FOG. Greater unpredictability in subthalamic beta rhythms was evident during stepping without freezing episodes in Freezers compared to Non-Freezers, whereas greater unpredictability in alpha rhythms was evident in Freezers during FOG. Non-linear analysis of dynamic neural signals during gait in freely moving people with PD may yield greater insight into the pathophysiology of FOG; whether the increases in STN entropy are causative or compensatory remains to be determined. Some beta LFP power may be useful for rhythmic, symmetric gait and DBS parameters, which completely attenuate STN beta power may worsen rather than improve FOG. •FOG was elicited with a novel turning and barrier gait task.•Freezers showed lower beta band power and higher beta entropy than Non-Freezers during locomotion without freezing.•Freezers showed increased alpha entropy during periods with freezing compared to periods without freezing.