High-volume pre-dilution on-line hemodiafiltration is the adequate blood purification method from the viewpoint of amino acid nutrition

• Published in: Renal Replacement Therapy Vol. 8; no. 1; pp. 1 - 5
• Main Authors: Kato, Motoko, Urabe, Shunichiro, Matsuzawa, Shohei, Kato, Akira, Fukazawa, Momoko, Hiyama, Emi, Kurii, Asami, Mikami, Noriko, Kitajima, Yukie, Hida, Miho, Kokubo, Kenichi, Hyodo, Toru
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 01.10.2022; BioMed Central; BMC
• Subjects: Amino acid; Diseases of the genitourinary system. Urology; Frailty; Medicine; Medicine & Public Health; Nephrology; Nutrition; Pre-dilution on-line hemodiafiltration; RC870-923; Frailty; Amino acid; Nutrition; Pre-dilution on-line hemodiafiltration
• ISSN: 2059-1381; 2059-1381
• DOI: 10.1186/s41100-022-00441-4

Background We compared amino acid leakage among high-volume pre-dilution on-line hemodiafiltration (Pre O-HDF), hemodialysis (HD), and post-dilution on-line hemodiafiltration (Post O-HDF). Subjects and methods The subjects were 9 patients. For HD, the total dialysate flow rate was established as 500 mL/min. For high-volume Pre O-HDF, it was established as 600 mL/min, under a replacement fluid volume of 90 L. For Post O-HDF, it was established as 600 mL/min, under a replacement fluid volume of 10 L. In both procedures, the duration of treatment was 4 h, and the blood flow volume was 200 mL/min. We compared the leakages of total amino acid, non-essential amino acid, and essential amino acid, clear spaces (CSs), β 2 -microglobulin (β 2 -MG) reduction rate, Kt/V for urea, and albumin leakage among the three procedures. Results Amino acid leakages after high-volume Pre O-HDF were significantly lower than HD and Post O-HDF. The CSs after high-volume Pre O-HDF were significantly lower than Post O-HDF. The β 2 -MG reduction rate after high-volume Pre O-HDF was significantly lower than Post O-HDF. The Kt/V for urea was not significantly different. Albumin leakages were below the detection limit (< 1 g) in the three procedures. Conclusion Under the treatment conditions we performed this time, high-volume Pre O-HDF reduces amino acid leakage in comparison with HD and Post O-HDF. High-volume Pre O-HDF is a therapeutic mode that suppresses amino acid leakage.