Effect of intestinal helminthiasis on intestinal permeability of early primary schoolchildren
Intestinal permeability of 246 early primary schoolchildren at 2 schools (106 of whom were infected with intestinal helminths) was assessed by using the lactulose/mannitol differential absorption test. The ratio of the urinary recoveries of lactulose and mannitol was determined after oral administra...
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Published in | Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 90; no. 6; pp. 666 - 669 |
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Main Authors | , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Oxford
Elsevier Ltd
01.11.1996
Royal Society of Tropical Medicine and Hygiene Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Intestinal permeability of 246 early primary schoolchildren at 2 schools (106 of whom were infected with intestinal helminths) was assessed by using the lactulose/mannitol differential absorption test. The ratio of the urinary recoveries of lactulose and mannitol was determined after oral administration of a standard solution of the 2 sugars. Assessment of intestinal permeability was repeated on 100 infected children after treatment and on a cohort of 68 uninfected children. Infected and uninfected groups were compared with respect to baseline lactulose/mannitol ratio (
L
M1
) and change in lactulose/mannitol ratio between assessments (
ΔL
M
). The correlations between baseline intensity of infection and
L
M1
, and between fall in intensity and
ΔL
M
, were evaluated. Based on a crude index of socioeconomic status, each child was assigned to one of 3 socioeconomic groups; all but 3 children belonged to either groups 2 or 3.
Trichuris trichiura and
Ascaris lumbricoides were the 2 predominant infections; the hookworm infection rate was relatively low. The results suggested that helminthiasis exerted only a marginal effect on intestinal permeability, the impact of which in children from lower socioeconomic backgrounds was negligible in comparison with the cumulative effects of other factors. |
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Bibliography: | istex:D30B3048190F10223CBF5920B9626070980455E6 Address for correspondence: S. Mahendra Raj, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia. ark:/67375/HXZ-HB93PJC5-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0035-9203 1878-3503 |
DOI: | 10.1016/S0035-9203(96)90425-3 |