Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition

• Published in: NPJ biofilms and microbiomes Vol. 7; no. 1; p. 41
• Main Authors: Chen, Po-Jung, Nakano, Toshiaki, Lai, Chia-Yun, Chang, Kuei-Chen, Chen, Chao-Long, Goto, Shigeru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/1762; 631/326/2522; 692/698/2741/2135; Biomedical and Life Sciences; Diarrhea; Dysbacteriosis; Fecal microflora; Feces; Food allergies; Homeostasis; Immunoglobulin E; Life Sciences; Light therapy; Medical Microbiology; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Microbiota; Phototherapy; Risk factors; Transplantation; Vitamin D3
• ISSN: 2055-5008; 2055-5008
• DOI: 10.1038/s41522-021-00213-8

The importance of sun exposure on human health is well recognized, and a recent trend in the avoidance of sun exposure has led to the risk of missing the beneficial effects such as vitamin D 3 biogenesis. Vitamin D 3 insufficiency is one of the risk factors for the development of food allergies (FAs), and vitamin D 3 status controls gut homeostasis by modulating the microbiota. This study aimed to explore the impact of daily full spectrum light exposure (phototherapy) on the pathogenesis of FAs. Phototherapy ameliorated allergic diarrhea and improved FA-associated vitamin D 3 insufficiency and dysbiosis. Fecal microbiota transplantation (FMT) of FA donor feces induced allergic diarrhea with OVA-specific IgE elevation in naïve mice. In contrast, FMT of naïve donor feces ameliorated allergic diarrhea in established FA mice, suggesting the involvement of the microbiota composition in FA. Phototherapy is an alternative approach for the prevention of FA-like allergic diarrhea through the modulation of vitamin D 3 status and microbiota composition.