Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

• Published in: Nature communications Vol. 11; no. 1; pp. 1 - 12
• Main Authors: Wang, Rui, Shi, Miusi, Xu, Feiyan, Qiu, Yun, Zhang, Peng, Shen, Kailun, Zhao, Qin, Yu, Jiaguo, Zhang, Yufeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 140/133; 140/146; 147/135; 147/143; 631/326/22; 639/166/985; 639/638/77/890; Amputation; Biocompatibility; Biomedical materials; Bone growth; Bone implants; Bones; Catalytic activity; Cell adhesion; Cell adhesion & migration; Cell differentiation; Drug resistance; Electron recombination; Health risks; Humanities and Social Sciences; Infections; multidisciplinary; Nanofibers; Orthopaedic implants; Orthopedics; Osteogenesis; Photocatalysis; Reactive oxygen species; Recombination; Regeneration; Science; Science (multidisciplinary); Surgical implants; Tissue engineering; Titanium; Titanium dioxide; Transplants & implants
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-18267-1

Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO 2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO 2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO 2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection. Infection is a growing issue in artificial implants and has become an area of significant interest. Here, the authors report on graphdiyne titanium dioxide composite nanofibres with enhanced photocatalytic reactive oxygen species generation and osteoinductive properties, demonstrated in infected implant models.