A Relationship Between Vascular Endothelial Growth Factor, Angiogenesis, and Cardiac Repair After Muscle Stem Cell Transplantation Into Ischemic Hearts

• Published in: Journal of the American College of Cardiology Vol. 50; no. 17; pp. 1677 - 1684
• Main Authors: Payne, Thomas R., PhD, Oshima, Hideki, MD, PhD, Okada, Masaho, MD, Momoi, Nobuo, MD, Tobita, Kimimasa, MD, Keller, Bradley B., MD, Peng, Hairong, MD, PhD, Huard, Johnny, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.10.2007; Elsevier Limited
• Subjects: Angiogenesis; Animals; Cardiology; Cardiomyocytes; Cardiovascular; Cells, Cultured; Coronary Circulation; Disease Models, Animal; Experiments; Heart attacks; Hypoxia; Internal Medicine; Male; Mice; Mice, Inbred NOD; Mice, SCID; Muscle, Skeletal - cytology; Musculoskeletal system; Myocardial Ischemia - metabolism; Myocardial Ischemia - pathology; Myocardial Ischemia - physiopathology; Myocardial Ischemia - surgery; Myocardium - pathology; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Neovascularization, Physiologic; Rodents; Stem Cell Transplantation; Stem cells; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Ventricular Function, Left; United States > US; California; PBS; sFlt1; MDSC; fskMyHC; soluble Flt1; VEGF; myocardial infarction; nLacZ; muscle-derived stem cell; LV; phosphate-buffered saline; FS; vascular endothelial growth factor; fast skeletal myosin heavy chain; nuclear-localized LacZ; left ventricle/ventricular; MI; fractional shortening
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.04.100

A Relationship Between Vascular Endothelial Growth Factor, Angiogenesis, and Cardiac Repair After Muscle Stem Cell Transplantation Into Ischemic Hearts Thomas R. Payne, Hideki Oshima, Masaho Okada, Nobuo Momoi, Kimimasa Tobita, Bradley B. Keller, Hairong Peng, Johnny Huard We examined whether vascular endothelial growth factor (VEGF) was associated with the angiogenic and therapeutic effects induced after transplantation of skeletal muscle-derived stem cells (MDSCs) into a myocardial infarction. To test this, we used a gain- or loss-of-VEGF function approach with MDSCs transplanted into infarcted hearts. Our results indicate that VEGF is essential for the induction of angiogenesis and functional improvements after MDSC transplantation, signifying an important relationship between VEGF, angiogenesis, and functional recovery for cardiac cell therapy.