Atypical frontoamygdala functional connectivity in youth with autism

Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-...

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Published inDevelopmental cognitive neuroscience Vol. 37; p. 100603
Main Authors Odriozola, Paola, Dajani, Dina R., Burrows, Catherine A., Gabard-Durnam, Laurel J., Goodman, Emma, Baez, Adriana C., Tottenham, Nim, Uddin, Lucina Q., Gee, Dylan G.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.06.2019
Elsevier
Subjects
Adolescence
Amygdala
Amygdala - physiopathology
Autism spectrum disorder (ASD)
Autism Spectrum Disorder - physiopathology
Child
Cross-Sectional Studies
Development
Humans
Magnetic Resonance Imaging - methods
Male
Original Research
Prefrontal cortex
Prefrontal Cortex - physiopathology
Resting-state functional connectivity
Development
Adolescence
Resting-state functional connectivity
Prefrontal cortex
Autism spectrum disorder (ASD)
Amygdala
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Summary:Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-related changes in frontoamygdala networks in ASD. Here we characterize frontoamygdala resting-state FC in a cross-sectional sample (ages 7–25) of 58 typically developing (TD) individuals and 53 individuals with ASD. Contrary to hypotheses, individuals with ASD did not show different age-related patterns of frontoamygdala FC compared with TD individuals. However, overall group differences in frontoamygdala FC were observed. Specifically, relative to TD individuals, individuals with ASD showed weaker frontoamygdala FC between the right basolateral (BL) amygdala and the rostral anterior cingulate cortex (rACC). These findings extend prior work to a broader developmental range in ASD, and indicate ASD-related differences in frontoamygdala FC that may underlie core socioemotional impairments in children and adolescents with ASD.
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These two authors contributed equally to this work.
ISSN:1878-9293
1878-9307
DOI:10.1016/j.dcn.2018.12.001