Post-translational modifications of tubulin: pathways to functional diversity of microtubules

Highlights • Tubulin modifications contribute to functional diversity of microtubules (MTs). • Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components. • Various PTMs overlap or localize to specific MT domains demonstrating heterogene...

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Bibliographic Details
Published inTrends in cell biology Vol. 25; no. 3; pp. 125 - 136
Main Authors Song, Yuyu, Brady, Scott T
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2015
Subjects
acetylation
Animals
detyrosination
Humans
microtubule
Microtubules - metabolism
Pathology
polyamination
polyglutamylation
Protein Processing, Post-Translational
tubulin
Tubulin - metabolism
microtubule
acetylation
tubulin
polyglutamylation
polyamination
detyrosination
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Summary:Highlights • Tubulin modifications contribute to functional diversity of microtubules (MTs). • Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components. • Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity. • PTMs vary with time, cell type, subcellular compartment, and physiological state.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2014.10.004