Bioinformatics analysis of the role of aldolase A in tumor prognosis and immunity

• Published in: Scientific reports Vol. 12; no. 1; p. 11632
• Main Authors: Tian, Wanjia, Zhou, Junying, Chen, Mengyu, Qiu, Luojie, Li, Yike, Zhang, Weiwei, Guo, Ruixia, Lei, Ningjing, Chang, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.07.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/67; Adenocarcinoma; Bioinformatics; Brain cancer; Brain research; Breast cancer; CD4 antigen; CD8 antigen; Enzymes; Esophagus; Gene expression; Gluconeogenesis; Glucose; Glycolysis; Head and neck carcinoma; Hepatocellular carcinoma; Humanities and Social Sciences; Immunity; Liver cancer; Lung cancer; Lung carcinoma; Lymphocytes; Lymphocytes T; Macrophages; Medical prognosis; Medical research; Metabolism; Metastases; multidisciplinary; Pancreatic cancer; Prognosis; Science; Science (multidisciplinary); Skin cancer; Squamous cell carcinoma; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-15866-4

Aldolase A (ALDOA) is an enzyme that plays an important role in glycolysis and gluconeogenesis, which is closely related to tumor metabolism. In this study, the overall roles of ALDOA in pan-cancer have been investigated from several aspects using databases and online analysis tools. Using the ONCOMINE database, the expression of ALDOA in various cancers was analyzed. The prognostic role of ALDOA was explored by PrognoScan, GEPIA, and Kaplan–Meier Plotter. The immune-related role of ALDOA and its downstream substrates was decided by TIMER, cBioPortal and String. Our data indicate that ALDOA expression level in lung adenocarcinoma, liver hepatocellular carcinoma, head and neck squamous cell carcinoma is higher than that in normal tissues. Increased expression of ALDOA often indicates a poor prognosis for patients. The correlation between ALDOA and immune infiltration among different tumors is very different. We also investigate the relationship between ALDOA and its upstream/downstream proteins. Our results showed that ALDOA could be used as a biomarker for the tumor prognosis, and could be correlated with the infiltrating levels of macrophages, CD4+ T cells and CD8+ T cells.