The TGF-β–Smad network: introducing bioinformatic tools

The TGF-β superfamily is an important class of intercellular signalling molecule, including TGF-β and bone morphogenetic proteins. Intracellular signalling cascades triggered by these molecules eventually activate transcription factors of the Smad family, which then regulate expression of their resp...

Full description

Saved in:
Bibliographic Details
Published inTrends in Genetics Vol. 18; no. 2; pp. 96 - 103
Main Authors Kloos, Dorothee U., Choi, Claudia, Wingender, Edgar
Format Book Review Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.02.2002
Elsevier Science
Subjects
Animals
Binding Sites
Biological and medical sciences
BMP
Databases, Factual
Diverse techniques
DNA - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Feedback, Physiological
Fundamental and applied biological sciences. Psychology
Humans
Molecular and cellular biology
Mutation
Neoplasms - genetics
Protein Conformation
Signal Transduction
signalling network
SMAD
Smad Proteins
Smad4 Protein
TAK1
TGF-beta
Trans-Activators - chemistry
Trans-Activators - genetics
Trans-Activators - metabolism
TRANSFAC
Transforming Growth Factor beta - metabolism
TGF-beta
BMP
TAK1
signalling network
Development
Cell biology
Genetics
SMAD
Bioinformatics
TRANSFAC
Transcription
Review
Gene expression
Mechanism
Molecules
Signal transduction
Target
Bone morphogenetic protein
Database
Intracellular
Transcription factor
Tool
Online AccessGet full text

Cover

More Information
Summary:The TGF-β superfamily is an important class of intercellular signalling molecule, including TGF-β and bone morphogenetic proteins. Intracellular signalling cascades triggered by these molecules eventually activate transcription factors of the Smad family, which then regulate expression of their respective target genes. This article will discuss the TGF-β–Smad signalling networks and how these processes are represented in databases of signal transduction and transcription control mechanisms. These databases can provide a well-structured overview of the subject and a basis for advanced bioinformatics analyses to interpret the function of genomic sequences or to analyse signalling networks. The TGF-beta-SMAD signalling network is examined using the signal transduction database, TRANSFAC.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0168-9525
DOI:10.1016/S0168-9525(02)02556-8