Central and peripheral neurotoxicity induced by the Jack Bean Urease (JBU) in Nauphoeta cinerea cockroaches

• Published in: Toxicology (Amsterdam) Vol. 368-369; pp. 162 - 171
• Main Authors: de Freitas, Thiago Carrazoni, de Avila Heberle, Marines, Perin, Ana Paula, Zanatta, Ana Paula, Rodrigues, Polyana Veloso, dos Santos, Fabiola Duarte Machado, de Almeida, Carlos Gabriel Moreira, Vaz Breda, Ricardo, dos Santos, Douglas Silva, Pinto, Paulo Marcos, da Costa, Jaderson Costa, Carlini, Dr. Celia Regina, Dal Belo, Dr. Cháriston André
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.08.2016
• Subjects: Acetylcholine - pharmacology; Acetylcholinesterase; Acetylcholinesterase - metabolism; Animals; Behavior modulation; Canavalia - enzymology; Canavalia ensiformis; Cholinergics; Cockroaches; Dose-Response Relationship, Drug; Emergency; Heart Rate - drug effects; Insecticides; Insecticides - pharmacology; Insects; Jack beans; Male; Nauphoeta cinerea; Neostigmine - pharmacology; Nervous System - drug effects; Neurotoxicity; Neurotoxins - pharmacology; Plant ureases; Searching; Spontaneous; Urease - pharmacology; AChE; SNCAP; canatoxin; DTNB; thionitrobenzoic acid; ACh; 5,5', dithiobis-(2-nitrobenzoic acid); Jack Bean Urease; acetylcholinesterase; TNB; behavior modulation; excitatory postsynaptic potentials; spontaneous neural compound action potentials; Nauphoeta cinerea; CNTX; GLU; Plant ureases; neurotoxicity; GABA; EPSPs; acetylcholine; JBU; glutamate; gama-aminobutiric acid; Acetylcholinesterase; Neurotoxicity; Behavior modulation
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2016.09.007

Highlights • Jack Bean Urease (JBU) alters behavior and physiology in Nauphoeta cinerea. • JBU induced a positive cardiac chronotropic effect in N. cinerea. • The cardiac effects of JBU rely on the insect cholinergic system. • JBU increased leg but not antennae grooming by an octopaminergic route. • JBU induces in vivo irreversible blockade of the coxal-adutor muscle in cockroaches.