Cyclodextrin-based pharmaceutics: past, present and future

Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pha...

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Published inNature reviews. Drug discovery Vol. 3; no. 12; pp. 1023 - 1035
Main Authors Brewster, Marcus E, Davis, Mark E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.12.2004
Subjects
Animals
Biopharmaceutics - methods
Biopharmaceutics - trends
Cyclodextrins
Cyclodextrins - administration & dosage
Cyclodextrins - chemistry
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Evaluation
Excipients - administration & dosage
Excipients - chemistry
Forecasting
Humans
Pharmaceutical industry
Pharmaceutical research
Physiological aspects
Polymers
Product development
United States
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Summary:Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1474-1776
1474-1784
DOI:10.1038/nrd1576