Cyclic nucleotide research - still expanding after half a century
Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal tra...
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Published in | Nature reviews. Molecular cell biology Vol. 3; no. 9; pp. 710 - 718 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.09.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor-effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Undefined-1 ObjectType-Feature-3 |
ISSN: | 1471-0072 1471-0080 |
DOI: | 10.1038/nrm911 |