Cyclic nucleotide research - still expanding after half a century

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal tra...

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Published inNature reviews. Molecular cell biology Vol. 3; no. 9; pp. 710 - 718
Main Authors Beavo, Joseph A, Brunton, Laurence L
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2002
Subjects
Animals
Cyclic AMP - history
Cyclic AMP - metabolism
Cyclic AMP Response Element-Binding Protein - metabolism
Cyclic GMP - history
Cyclic GMP - metabolism
History, 20th Century
History, 21st Century
Humans
Nobel Prize
Second Messenger Systems
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Summary:Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor-effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm911