Inhibitory effect of 5,6-dihydroergosteol-glucoside on atopic dermatitis-like skin lesions via suppression of NF-κB and STAT activation

• Published in: Journal of dermatological science Vol. 79; no. 3; pp. 252 - 261
• Main Authors: Jung, Mira, Lee, Tae Hoon, Oh, Hyun Jeoung, Kim, Hakwon, Son, Youngsook, Lee, Eunjoo H, Kim, Jiyoung
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.09.2015
• Subjects: 5,6-Dihydroergosterol-glucoside; Administration, Cutaneous; Animals; Anti-Inflammatory Agents - pharmacology; Atopic dermatitis; Cell Line; chemokine; Chemokine CCL17 - genetics; Chemokine CCL17 - metabolism; Chemokine CCL22 - genetics; Chemokine CCL22 - metabolism; Dermatitis, Atopic - chemically induced; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - immunology; Dermatology; Dinitrochlorobenzene; Eosinophils; Epidermis - immunology; Ergosterol - analogs & derivatives; Ergosterol - pharmacology; Glucosides - pharmacology; Histamine - blood; Humans; Immunoglobulin E - blood; Interferon-gamma - pharmacology; Keratinocytes; Macrophage-derived chemokine; Male; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B - metabolism; NF-κB; RNA, Messenger - blood; STAT; STAT1 Transcription Factor - metabolism; Thymus and activation-regulated; Tumor Necrosis Factor-alpha - pharmacology; NF-κB; chemokine; Macrophage-derived chemokine; STAT; Thymus and activation-regulated; Atopic dermatitis; 5,6-Dihydroergosterol-glucoside
• ISSN: 0923-1811; 1873-569X
• DOI: 10.1016/j.jdermsci.2015.06.005

Highlights • DHE-Glc attenuates AD-like skin inflammatory symptoms in mice. • DHE-Glc suppresses TNF-α/IFN-γ induced TARC and MDC in HaCaT keratinocytes. • DHE-Glc inhibits phosphorylation of p38 and JAK2 in TNF-α/IFN-γ induced HaCaT. • DHE-Glc suppresses NF-κB and STAT1 activation by TNF-α/IFN-γ in HaCaT. • DHE-Glc attenuates skin inflammatory response in vitro and in vivo.