Bioactivity in glass/PMMA composites used as drug delivery system

Gentamicin sulfate has been incorporated in composites prepared from a SiO 2–CaO–P 2O 5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic...

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Bibliographic Details
Published inBiomaterials Vol. 22; no. 7; pp. 701 - 708
Main Authors Arcos, D., Ragel, C.V., Vallet-Regı́, M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.2001
Elsevier Science
Subjects
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Bioactive glasses
Biocompatible Materials
Biological and medical sciences
Body Fluids
Bone Cements
Bone Substitutes
Delayed-Action Preparations
Drug Delivery Systems
Gentamicin release
Gentamicins - administration & dosage
Gentamicins - pharmacokinetics
Glass
Humans
In vitro bioactivity
In Vitro Techniques
Materials Testing
Medical sciences
Microscopy, Electron, Scanning
Osteomyelitis - prevention & control
PMMA–glass composites
Polymethyl Methacrylate
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
In vitro bioactivity
PMMA–glass composites
Gentamicin release
Bioactive glasses
Delivery system
Control release polymer
Gentamicin
Glass
Methyl methacrylate polymer
Bioactive material
In vitro
Composite material
Surface structure
Antibiotic
Aminoglycoside
Antibacterial agent
Release
Biomedical engineering
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Summary:Gentamicin sulfate has been incorporated in composites prepared from a SiO 2–CaO–P 2O 5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic during the first hours when they are soaked in simulated body fluid (SBF). Thereafter, a slower drug release is produced, supplying ‘maintenance’ doses until the end of the experiment. The gentamicin release rate is related with the ionic Ca 2+ and H 3O + exchange between composite and SBF. The porous structure of the composites allows the growth of hydroxycarbonate apatite on the surface and into the pores.
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ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(00)00233-7