Physiological properties of Cantor coding-like iterated function system in the hippocampal CA1 network

• Published in: Cognitive neurodynamics Vol. 15; no. 4; pp. 733 - 740
• Main Authors: Fukushima, Yasuhiro, Yamaguti, Yutaka, Kuroda, Shigeru, Aihara, Takeshi, Tsuda, Ichiro, Tsukada, Minoru
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.08.2021; Springer Nature B.V
• Subjects: Amplitudes; Artificial Intelligence; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brief Communication; Clustering; Coding; Cognitive Psychology; Computer Science; Electrodes; Excitatory postsynaptic potentials; Experiments; Hippocampus; Learning; Neural coding; Neurons; Neurosciences; Physiology; Pyramidal cells; Sequences; γ-Aminobutyric acid A receptors; Japan; Iterated function system; Single neuron; Patch-clamp recording; Spatiotemporal coding; Hippocampus
• ISSN: 1871-4080; 1871-4099
• DOI: 10.1007/s11571-020-09648-9

Cantor coding provides an information coding scheme for temporal sequences of events. In the hippocampal CA3–CA1 network, Cantor coding-like mechanism was observed in pyramidal neurons and the relationship between input pattern and recorded responses could be described as an iterated function system. However, detailed physiological properties of the system in CA1 remain unclear. Here, we performed a detailed analysis of the properties of the system related to the physiological basis of learning and memory. First, we investigated whether the system could be simply based on a series of on–off responses of excitatory postsynaptic potential (EPSP) amplitudes. We applied a series of three spatially distinct input patterns with similar EPSP peak amplitudes. The membrane responses showed significant differences in spatial clustering properties related to the iterated function system. These results suggest that existence of some factors, which do not simply depend on a series of on–off responses but on spatial patterns in the system. Second, to confirm whether the system is dependent on the interval of sequential input, we applied spatiotemporal sequential inputs at several intervals. The optimal interval was 30 ms, similar to the physiological input from CA3 to CA1. Third, we analyzed the inhibitory network dependency of the system. After GABA A receptor blocker (gabazine) application, quality of code discrimination in the system was lower under subthreshold conditions and higher under suprathreshold conditions. These results suggest that the inhibitory network increase the difference between the responses under sub- and suprathreshold conditions. In summary, Cantor coding-like iterated function system appears to be suitable for information expression in relation to learning and memory in CA1 network.