Exposing the Molecular Machinery of BK Polyomavirus

BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues’ (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing developm...

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Bibliographic Details
Published inStructure (London) Vol. 24; no. 4; p. 495
Main Author Buck, Christopher B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 05.04.2016
Subjects
Assembly
Biology
BK Virus
Kidney Transplantation
Models, Molecular
Molecular structure
Organs
Pathogens
Platforms
Polyomavirus
Polyomavirus Infections
Vaccines
Viruses
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Summary:BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues’ (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing development of therapeutic antibodies and vaccines targeting this potentially deadly virus. The study also serves as a platform for exploring the basic biology of virion assembly and infectious entry. BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues’ (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing development of therapeutic antibodies and vaccines targeting this potentially deadly virus. The study also serves as a platform for exploring the basic biology of virion assembly and infectious entry.
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ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2016.03.011