The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk

• Published in: Thrombosis research Vol. 122; no. 6; pp. 736 - 742
• Main Authors: Tsantes, Argirios E, Nikolopoulos, Georgios K, Bagos, Pantelis G, Bonovas, Stefanos, Kopterides, Petros, Vaiopoulos, Georgios
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.01.2008; Elsevier
• Subjects: 4G/5G polymorphism; Biological and medical sciences; Blood and lymphatic vessels; Brain Ischemia - etiology; Brain Ischemia - genetics; Cardiology. Vascular system; Cardiovascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Hematology, Oncology and Palliative Medicine; Humans; Medical sciences; PAI-1; Pharmacology. Drug treatments; Plasminogen Activator Inhibitor 1 - genetics; Polymorphism, Genetic; Prognosis; Stroke - etiology; Stroke - genetics; Thrombosis - etiology; Thrombosis - genetics; Thrombotic risk; Vasodilator agents. Cerebral vasodilators; Venous Thromboembolism - etiology; Venous Thromboembolism - genetics; PAI-1; 4G/5G polymorphism; Thrombotic risk; Vascular disease; Plasminogen activator inhibitor 1; Risk factor; Cardiovascular disease; Thrombosis; Polymorphism
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2007.09.005

Abstract Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma PAI-1. The 4G allele is associated with higher levels of PAI-1, and might increase the risk for intravascular thrombosis. However, the contribution of this genetic variant to the risk for thrombosis, both arterial and venous, has not been clearly established. A broad spectrum of findings regarding the effect of the 4G allele on thrombotic risk in different target organs has been reported. Our aim is to summarize the variable influence of this polymorphism on thrombotic events in different tissues or organs and explain the underlying mechanisms accounting for these differences.