Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-one health...
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Published in | Scientific reports Vol. 11; no. 1; p. 16269 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
11.08.2021
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
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Summary: | The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-one healthy participants were recruited, the facial skin characteristics of each donor were investigated, their skin bacterial DNA was isolated and metagenomic analysis was performed. The donors were divided into two groups for age and sex each to analyze their skin microbiomes. Moreover, we investigated the correlation between the skin microbiome and clinical characteristics. The alpha diversity of the skin microbiome was significantly higher in the elderly, and beta diversity was significantly different according to age. The comparative skin microbials showed that the genus
Lawsonella
was more abundant in the younger age group, and
Enhydrobacter
was predominant in the older age group.
Staphylococcus
and
Corynebacterium
were more abundant in males, while
Lactobacillus
was more abundant in females.
Lawsonella
had a negative correlation with skin moisture and brown spots.
Staphylococcus
and
Corynebacterium
both had negative correlations with the number of UV spots and positive correlations with transepidermal water loss (TEWL). Furthermore,
Staphylococcus aureus
had a negative correlation with skin moisture parameters. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-021-95734-9 |