Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome

• Published in: Data in brief Vol. 13; pp. 202 - 207
• Main Authors: Bina, Minou, Wyss, Phillip, Song, Xiaohui C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2017; Elsevier
• Subjects: CpG-rich motifs; Data; Gene regulation; Genomic imprinting; KMT2A; MLL1 morphemes; Mouse genome; ZFP57 binding site; MLL1 morphemes; KMT2A; Gene regulation; Mouse genome; CpG-rich motifs; Genomic imprinting; ZFP57 binding site
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2017.05.050

While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the data repository at Purdue University, for downloading the positions of the MLL1 morphemes, the ZFP57 binding site, and the ZFBS-Morph overlaps in the mouse genome.