A Paradoxical Effect of Bronchodilators

Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp...

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Bibliographic Details
Published inChest Vol. 111; no. 6; pp. 1766 - 1767
Main Authors Maury, Eric, Ioos, Vincent, Lepecq, Béatrice, Guidet, Bertrand, Offenstadt, Georges
Format Journal Article
LanguageEnglish
Published Northbrook, IL Elsevier Inc 01.06.1997
American College of Chest Physicians
Elsevier B.V
Subjects
Acidosis, Lactic - chemically induced
Acute Disease
Adrenergic beta-Agonists - adverse effects
Albuterol - adverse effects
Asthma - complications
Asthma - drug therapy
asthma, beta-2 agonists
Biological and medical sciences
Bronchodilator agents
Bronchodilator Agents - adverse effects
Causes of
Complications and side effects
Drug toxicity and drugs side effects treatment
Dyspnea - chemically induced
Humans
Lactic acidosis
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
lactic acidosis
asthma, beta-2 agonists
Case study
Human
Intravenous administration
Hyperlactacidemia
Toxicity
Bronchodilator
Metabolic diseases
β2-Adrenergic receptor
β-Adrenergic receptor agonist
Salbutamol
Metabolic acidosis
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Summary:Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.
ISSN:0012-3692
1931-3543
DOI:10.1378/chest.111.6.1766