MAPK signal pathways in the regulation of cell proliferation in mammalian cells

ABSTRACT MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above...

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Bibliographic Details
Published inCell research Vol. 12; no. 1; pp. 9 - 18
Main Authors ZHANG, Wei, LIU, Hui Tu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2002
Nature Publishing Group
The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Subjects
Animals
Biomedical and Life Sciences
Cell Biology
Cell Cycle
Cell Division - physiology
Humans
Life Sciences
Mammals
MAP Kinase Signaling System - physiology
MAPK
review
Signal Transduction
促细胞分裂剂活化蛋白激酶
哺乳动物
细胞增殖
JNK/SPAK
p38
cell proliferation
MAPK
cross-talk
ERK
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ISSN1001-0602
1748-7838
DOI10.1038/sj.cr.7290105

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Summary:ABSTRACT MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation.
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ISSN:1001-0602
1748-7838
DOI:10.1038/sj.cr.7290105