Recent Insights into the Role of DNA Methylation and Histone Modifications in Systemic Sclerosis: A Scoping Review

Systemic sclerosis is a complex idiopathic disease originating from an intricate interplay between genetic susceptibility, environmental factors, and epigenetic modifications. This scoping review aims to map the advancements made regarding DNA methylation abnormalities and histone modifications in s...

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Published inDiagnostics (Basel) Vol. 14; no. 6; p. 652
Main Authors Kostova, Tsvetelina, Karalilova, Rositsa, Batalov, Zguro, Kazakova, Maria, Sarafian, Victoria, Batalov, Anastas
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2024
MDPI
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Summary:Systemic sclerosis is a complex idiopathic disease originating from an intricate interplay between genetic susceptibility, environmental factors, and epigenetic modifications. This scoping review aims to map the advancements made regarding DNA methylation abnormalities and histone modifications in systemic sclerosis in the past decade. A literature search was conducted using three electronic databases (Scopus, Web of Science and PubMed) to identify relevant articles. A total of 44 studies were selected for this review, demonstrating the critical contribution of epigenetic perturbations in multiple cell types to disease pathogenesis. In conclusion, this scoping review has elucidated the significant discoveries made in the past decade regarding the role of DNA methylation and histone modifications in systemic sclerosis. Further progress in the field could lead to the development of novel treatment possibilities targeting epigenetic marks.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14060652