Axonal injury in reverse

Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) (pages 495-499), suggesting the use of neuroregenerative as well as neuroprotective drugs as potenti...

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Bibliographic Details
Published inNature medicine Vol. 17; no. 4; pp. 423 - 425
Main Authors Craner, Matt J, Fugger, Lars
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.04.2011
Subjects
Animals
Axons
Axons - pathology
Diagnosis
Encephalomyelitis, Autoimmune, Experimental - etiology
Encephalomyelitis, Autoimmune, Experimental - pathology
Health aspects
Humans
Magnetic resonance imaging
Mice
Models, Neurological
Multiple sclerosis
Multiple Sclerosis - etiology
Multiple Sclerosis - pathology
Nerve Degeneration - pathology
Neurodegeneration
Neurology
Neurons
Neuroprotective agents
Physiological aspects
Risk factors
United Kingdom
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Summary:Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) (pages 495-499), suggesting the use of neuroregenerative as well as neuroprotective drugs as potential therapies for multiple sclerosis.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
ObjectType-Commentary-2
content type line 66
ISSN:1078-8956
1546-170X
DOI:10.1038/nm0411-423