ENHANCING EFFECT OF PREADMINISTRATION OF CARBON TETRACHLORIDE ON METHYLAZOXYMETHANOL ACETATE-INDUCED INTESTINAL CARCINOGENESIS

• Published in: Journal of toxicological sciences Vol. 10; no. 4; pp. 289 - 293
• Main Authors: KATO, Kazuo, KAWAI, Toshiro, FUJII, Masahiko, BUNAI, Yasuo, SHIMA, Hiroto, TAKAHASHI, Masayoshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Toxicology 1985; Japanese Society of Toxicology; Japan Science and Technology Agency
• Subjects: Adenocarcinoma - chemically induced; Adenocarcinoma, Mucinous - chemically induced; Adenoma - chemically induced; Animals; Azo Compounds - toxicity; Biological and medical sciences; Carbon Tetrachloride - administration & dosage; Carbon Tetrachloride - toxicity; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; Drug Synergism; Female; Intestinal Neoplasms - chemically induced; Liver - pathology; Male; Medical sciences; methylazoxymethanlol acetate; Methylazoxymethanol Acetate - toxicity; Rats; Rats, Inbred ACI; Tumors; Carcinogen; Vertebrata; Mammalia; Rat; Toxicity; Animal; Carbon tetrachloride; Rodentia; Gut; Digestive diseases; Tumor; Solvent
• ISSN: 0388-1350; 1880-3989
• DOI: 10.2131/jts.10.289

This study concerns the modifying effect of carbon tetra-chloride (CCl4) on methylazoxymethanol acetate (MAM)-induced intestinal carcinogenesis in ACI rats of both sexes. Forty five animals were given CCl4 (0.5 ml/kg body weight) through a stomach tube, followed by an i. p. injection with MAM (25 mg/kg body weight) 24 hours after CCl4 treatment. The paired administrations were done once a week for 4 weeks and animals were observed until sacrifice 30 weeks later. Pretreatment with CCl4 caused not only early death from chemical toxicity of MAM but also an increase in small-bowel tumors.