EFFECTS OF POSTNATAL LOW-LEVELS OF EXPOSURE TO STYRENE ON BEHAVIOR AND DEVELOPMENT IN RATS

Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. Compared to control group, Styrene-exposed groups showed significant delay in the following developmenta...

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Bibliographic Details
Published inJournal of toxicological sciences Vol. 14; no. 4; pp. 279 - 286
Main Authors SHIGETA, Sadayoshi, MIYAKE, Kumiko, AIKAWA, Hiroyuki, MISAWA, Tetsuo
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Toxicology 1989
Japanese Society of Toxicology
Japan Science and Technology Agency
Subjects
Animals
Animals, Newborn - physiology
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Biological and medical sciences
Body Weight - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
development
Exploratory Behavior - drug effects
Female
Growth - drug effects
Male
Medical sciences
Rats
Sex Factors
Solvents
Styrenes - toxicity
Toxicology
Psychomotor development
Organic solvent
Vertebrata
Mammalia
Rat
Toxicity
Newborn animal
Rodentia
Styrene
Behavior
Postnatal development
Inhalation
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Summary:Three groups of rats were exposed by inhalation to either clean air (control group) or styrene monomer at 25 and 50 ppm (styrene-exposed groups) for 7 h/day, 6 day/week, from 1 to 48 days of age. Compared to control group, Styrene-exposed groups showed significant delay in the following developmental indices : body weight gain, appearance of pinna detachment and incisor eruption. With respect to open-field activity, the styrene groups indicated longer latency to enter the field, less number of squares crossed and fewer rearings than those of controls. In the avoidance behavior aspect, the styrene groups attained less achievement level in avoidance rates than that of the control group. Dose-related trends were found between the two exposed groups in body weight increment, exploratory and avoidance behavior. Sex differences were seen on these factors also. These results suggest that at postnatal exposure of low-levels to styrene affects behavior and development in rats.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.14.279