Long-Term Administration of Cod Liver Oil Ameliorates Cognitive Impairment Induced by Chronic Stress in Rats

• Published in: Lipids Vol. 46; no. 5; pp. 417 - 423
• Main Authors: Trofimiuk, Emil, Braszko, Jan J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.05.2011; Springer‐Verlag; Springer Nature B.V
• Subjects: Animals; Anxiety; Avoidance Learning - physiology; Barnes maze; Biomedical and Life Sciences; Body weight; Cod liver oil; Cod Liver Oil - therapeutic use; Cognition Disorders - diet therapy; Cognition Disorders - etiology; Cognitive ability; Data processing; Docosahexaenoic acid; Docosahexaenoic Acids - therapeutic use; Eicosapentaenoic acid; Eicosapentaenoic Acid - therapeutic use; Elevated plus maze; Fatty acids; Fish oils; Life Sciences; Lipidology; Lipids; Locomotor activity; Male; Maze Learning - physiology; Medical Biochemistry; Medicinal Chemistry; Microbial Genetics and Genomics; Neurochemistry; Nutrition; Open field; Open-field behavior; Original Article; Passive avoidance; Rats; Rats, Wistar; Short term memory; Spatial memory; Stress; Stress, Physiological - physiology; Elevated plus maze; Passive avoidance; Barnes maze; Open field; Stress; Cod liver oil; Spatial memory
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/s11745-011-3551-3

Cod liver oil (CLO) is a rich source of omega-3 fatty acids (FA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The existing data suggest that EPA and DHA are the active agents of fish oil. In this study, we tested a hypothesis that the active constituents of CLO alleviate the negative impact of prolonged restraint stress on cognitive functions of male Wistar rats. Specifically, we attempted to characterize the preventive action of long-lasting treatment with CLO [0.375 ml/100 g body weight (equivalent to a dose of 300 mg/kg DHA and 225 mg/kg EPA), p.o. for 21 days] against an impairment caused by chronic restraint stress (2 h daily for 21 days) on recall as tested in a passive avoidance situation and on the spatial reference and working memory tested in a Barnes maze as well as on locomotor activity and anxiety behavior tested respectively in an open field and elevated plus-maze. We found that CLO administration statistically significantly ( p  < 0.01, both) prevented the deleterious effects of chronic restraint stress on recall and the spatial memory.