An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: awaiting peer review]

• Published in: F1000 research Vol. 9; p. 653
• Main Authors: Han, Jiahuai, Wu, Jianfeng, Silke, John
• Format: Journal Article
• Language: English
• Published: London Faculty of 1000 Ltd 2020; F1000 Research Limited; F1000 Research Ltd
• Subjects: Cellular stress response; Cloning; Cyclin-dependent kinases; Kinases; Lymphocytes; Mammals; Phosphatase; Phosphorylation; Proteins; Review; T cell receptors; Transcription factors; p38; MAPK; inflammation; signalling

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the...