An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: awaiting peer review]

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the...

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Bibliographic Details
Published inF1000 research Vol. 9; p. 653
Main Authors Han, Jiahuai, Wu, Jianfeng, Silke, John
Format Journal Article
LanguageEnglish
Published London Faculty of 1000 Ltd 2020
F1000 Research Limited
F1000 Research Ltd
Subjects
Cellular stress response
Cloning
Cyclin-dependent kinases
Kinases
Lymphocytes
Mammals
Phosphatase
Phosphorylation
Proteins
Review
T cell receptors
Transcription factors
p38
MAPK
inflammation
signalling
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Summary:The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.
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No competing interests were disclosed.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.22092.1