An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: awaiting peer review]
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the...
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| Published in | F1000 research Vol. 9; p. 653 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Faculty of 1000 Ltd
2020
F1000 Research Limited F1000 Research Ltd |
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| Abstract | The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38. |
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| AbstractList | The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38. The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38. |
| Author | Han, Jiahuai Wu, Jianfeng Silke, John |
| Author_xml | – sequence: 1 givenname: Jiahuai surname: Han fullname: Han, Jiahuai email: jiahuaihan@xmu.edu.cn organization: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361005, China – sequence: 2 givenname: Jianfeng surname: Wu fullname: Wu, Jianfeng organization: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361005, China – sequence: 3 givenname: John orcidid: 0000-0002-7611-5774 surname: Silke fullname: Silke, John email: silke@wehi.edu.au organization: Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3050, Australia |
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| Copyright | Copyright: © 2020 Han J et al. Copyright: © 2020 Han J et al. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2020 Han J et al. 2020 |
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| SubjectTerms | Cellular stress response Cloning Cyclin-dependent kinases Kinases Lymphocytes Mammals Phosphatase Phosphorylation Proteins Review T cell receptors Transcription factors |
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| Title | An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: awaiting peer review] |
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