Evaluation of Cyclodextrin Polymer as an Additive for Furosemide Tablet

The effectiveness of cyclodextrin polymer as a disintegrating agent for directly compressed tablets containing furosemide, cyclodextrin polymer and microcrystalline cellulose was investigated. Regression analysis based on statistically designed experiments made it possible to determine how various t...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 32; no. 2; pp. 670 - 677
Main Authors FENYVESI, EVA, TAKAYAMA, KOZO, SZEJTLI, JOZSEF, NAGAI, TSUNEJI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1984
Maruzen
Japan Science and Technology Agency
Subjects
Biological and medical sciences
Cellulose
Cyclodextrins
Dextrins
Drug Compounding
Excipients
Furosemide - administration & dosage
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
stability
Starch
Tablets
Tablet
Vehicle(excipient)
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Summary:The effectiveness of cyclodextrin polymer as a disintegrating agent for directly compressed tablets containing furosemide, cyclodextrin polymer and microcrystalline cellulose was investigated. Regression analysis based on statistically designed experiments made it possible to determine how various tablet characteristics are affected by the amount of excipients. As a result of computer optimization an optimum formulation was obtained exhibiting high dissolution rate, sufficient dissolution stability, fast disintegration, high hardness immediately after preparation and adequate hardness after ageing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.670