ERADicating stem cells from their niche

Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopo...

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Bibliographic Details
Published inNature cell biology Vol. 22; no. 10; pp. 1155 - 1157
Main Authors Lam, Kentson, Signer, Robert A J
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.10.2020
Subjects
Bone marrow
Cell surface
Cellular proteins
Endoplasmic reticulum
Endoplasmic Reticulum-Associated Degradation
Genetic aspects
Genotype & phenotype
Growth
Hematopoietic Stem Cells
Homeostasis
Physiology
Properties
Protein expression
Protein folding
Proteins
Quality control
Regenerative medicine
Stem cell research
Stem cells
United States
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Summary:Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.
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ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-020-00585-7