Antifungal activity of some Brazilian Hypericum species

• Published in: Phytomedicine (Stuttgart) Vol. 12; no. 3; pp. 236 - 240
• Main Authors: Fenner, R., Sortino, M., Kuze Rates, S.M., Dall’Agnol, R., Ferraz, A., Bernardi, A.P., Albring, D., Nör, C., von Poser, G., Schapoval, E., Zacchino, S.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.03.2005; Urban & Fischer Verlag; Elsevier Science Ltd
• Subjects: Agar dilution method; animal pathogenic fungi; Antifungal activity; Antifungal agents; Antifungal Agents - administration & dosage; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; antifungal properties; Candida; Candida - drug effects; Candida albicans; Humans; Hypericum; keratinophilic fungi; medicinal plants; Microbial Sensitivity Tests; Phytotherapy; Plant Components, Aerial; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; St. John's wort; Trichophyton mentagrophytes; Trichophyton rubrum; Brazil; United States; Antifungal activity; Agar dilution method; Hypericum
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2003.11.004

Crude methanolic extracts and fractions from the aerial parts of seven species of Hypericum ( H. caprifoliatum Cham. and Schltdl., H. carinatum Griseb., H. connatum Lam., H. ternum A. St.-Hil., H. myrianthum Cham. and Schltdl., H. piriai Arechav. and H. polyanthemum Klotzsch ex Reichardt) growing in southern Brazil were analyzed for their in vitro antifungal activity against a panel of standardized and clinical opportunistic pathogenic yeasts and filamentous fungi, including dermatophytes, by the agar dilution method. Chloroform and hexane extracts of H. ternum showed the greatest activity among extracts tested.