Role of plasmalemmal caveolae in signal transduction
Departments of 1 Pediatrics and 2 Cell Biology and Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9063 Caveolae are specialized plasmalemmal microdomains originally studied in numerous cell types for their involvement in the transcytosis of macromolecu...
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Published in | American journal of physiology. Lung cellular and molecular physiology Vol. 275; no. 5; pp. 843 - L851 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.11.1998
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Subjects | |
Online Access | Get full text |
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Summary: | Departments of 1 Pediatrics and
2 Cell Biology and Neuroscience,
University of Texas Southwestern Medical Center at Dallas, Dallas,
Texas 75235-9063
Caveolae are
specialized plasmalemmal microdomains originally studied in numerous
cell types for their involvement in the transcytosis of macromolecules.
They are enriched in glycosphingolipids, cholesterol, sphingomyelin,
and lipid-anchored membrane proteins, and they are characterized by a
light buoyant density and resistance to solubilization by Triton X-100
at 4°C. Once the identification of the marker protein caveolin made
it possible to purify this specialized membrane domain, it was
discovered that caveolae also contain a variety of signal transduction
molecules. This includes G protein-coupled receptors, G proteins and
adenylyl cyclase, molecules involved in the regulation of intracellular
calcium homeostasis, and their effectors including the endothelial
isoform of nitric oxide synthase, multiple components of the tyrosine kinase-mitogen-activated protein kinase pathway, and numerous lipid
signaling molecules. More recent work has indicated that caveolae
further serve to compartmentalize, modulate, and integrate signaling
events at the cell surface. This specialized plasmalemmal domain
warrants direct consideration in future investigations of both normal
and pathological signal transduction in pulmonary cell types.
adenylyl cyclase; caveolin; cholesterol; endothelial nitric oxide
synthase; mitogen-activated protein kinase |
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ISSN: | 1040-0605 0002-9513 1522-1504 |
DOI: | 10.1152/ajplung.1998.275.5.l843 |